L-Anap

fluorescent unnatural amino acid

Fluorescently label any proteinwith a single amino acid substitution!

What is L-Anap?


L-Anap allows researchers to fluorescently label any protein with a single amino acid substitution.

AsisChem is the only commercial supplier of L-Anap, which was was first synthesized by Chaterjee et al[1]. We supply two versions of L-ANAP: the first is a trifluoroacetate salt (L-ANAP*TFA), the other is a methyl ester derivative (L-ANAP-OMe), that relies on cellular esterase activity to enter cells non-reversibly.

Our synthesis of L-ANAP-OMe has been verified to work with the same tRNA/synthetase pair that has been used for successful incorporation into proteins in yeast[2], xenopus oocytes[3], and multiple mammalian cell types[4] including HEK293 and CHO cells and is available through Addgene.

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About AsisChem


AsisChem is a global leader in medicinal chemistry, custom synthesis and compound sourcing and delivery. AsisChem is the only U.S. company that leverages expert chemistry teams in St. Petersburg, Russia to support drug discovery projects and custom chemistry worldwide.

AsisChem provides an innovative and comprehensive range of building blocks. We supply scientists worldwide with the basic research tools necessary for advancing science and meeting unmet medical needs. Our commitment to researchers is to offer the highest quality products with competitive pricing in a collaborative environment.

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Literature References


  1. A. Chatterjee, J. Guo, H. S. Lee, P. G. Schultz, Journal of the American Chemical Society 135, 12540–3 (2013).
  2. Q. Wang, L. Wang, Journal of the American Chemical Society 130, 6066–7 (2008).
  3. T. Kalstrup, R. Blunck, Proceedings of the National Academy of Sciences of the United States of America 110, 8272–7 (2013).
  4. A. Chatterjee, J. Guo, H. S. Lee, P. G. Schultz, Journal of the American Chemical Society 135, 12540–3 (2013).
  5. L. Wang, J. Xie, P. G. Schultz, Annual review of biophysics and biomolecular structure 35, 225–49 (2006).
  6. T. K. Aman, S. E. Gordon, and W. N. Zagotta, Neuron review, p.M116.723932 (2016).
  7. S. E. Gordon, E. N. Senning, T. K. Aman, and W. N. Zagotta, The Journal of General Physiology, 147 (2 ), p.jgp.201511530 (2016).
  8. W. N. Zagotta, M. T. Gordon, E. N. Senning, M. A. Munari, and S. E. Gordon, The Journal of General Physiology, 147 (2 ), p.jgp.201511531 (2016).

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